Αποτελέσματα Αναζήτησης
Nutritional interventions for mitochondrial disorders regulated by U.S. Food and Drug Administration (FDA) that were included within the scope of this workshop fall into three general categories: (1) dietary supplements (2) medical foods, such as those used with the ketogenic diet; and (3) FDA-approved drugs that are also available as dietary ...
12 Ιουν 2024 · Specialists in the Mitochondrial Disease Clinic evaluate many types of mitochondrial diseases. Alpers progressive sclerosing poliodystrophy (Alpers disease). Barth syndrome.
Certain dietary supplements may be of value in treating PMDs because, as nutrients and metabolic cofactors, they help increase mitochondrial ATP production, bypass a cellular defect (e.g., a deficiency in the activity of complexes I, II, or III in the ETC), or remove toxic metabolites [9, 14].
Both nonpharmacological therapy (calcium and vitamin D supplementation, weight-bearing exercise, and fall prevention) and pharmacological treatments (antiresorptive and anabolic agents) may be helpful in the prevention and treatment of osteoporosis.
This review is aimed at a general medical and neurologist readership and provides a clinical approach to the recognition, investigation, and treatment of mitochondrial myopathies. Emphasis is placed on practical management considerations while including some recent updates in the field.
Treatment of mitochondrial neuropathies is symptomatic and follows guidelines established for the care of nonmitochondrial neuropathies. Caution and close monitoring is needed if medications causing mitochondrial toxicity are used. Valproate should be avoided as a potential treatment, especially in patients with POLG mutations.
Mitochondrial myopathies are mitochondrial diseases that cause prominent muscular symptoms such as muscle weakness and usually present with a multitude of symptoms and can affect virtually all organ systems. There is no cure for these diseases as of today. Treatment is generally supportive and emphasizes symptom management.
