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Explore Mayo Clinic studies testing new treatments, interventions and tests as a means to prevent, detect, treat or manage this condition. Lifestyle and home remedies. Some lifestyle changes may help ease your Parkinson's disease symptoms. But certain medicines can make your symptoms worse.
Eugenia Trushina, Ph.D., of the Mitochondrial Neurobiology and Therapeutics Lab at Mayo Clinic studies new treatments for Alzheimer's, Parkinson's, Huntington's, multiple sclerosis and other diseases.
12 Ιουν 2024 · Depending on the specific type of mitochondrial disease, common symptoms include muscle weakness, imbalance, gastrointestinal problems, poor growth, liver disease, heart disease, diabetes, visual and hearing issues, lactic acidosis, and developmental delays. Mitochondrial disease may be inherited.
5 Ιαν 2021 · Therefore, selecting the right patients, at the right time, and using targeted combination treatments, may offer the best chance for development of an effective novel therapy targeting mitochondrial dysfunction in Parkinson's disease.
Abstract. Parkinson’s disease (PD) is marked by widespread neurodegeneration in the brain in addition to a selective yet prominent and progressive loss of nigrostriatal dopaminergic neurons. Of the multiple theories suggested in the pathogenesis of PD, mitochondrial dysfunction takes a center stage in both sporadic and familial forms of illness.
In the past few years, medications emerged to help patients with mitochondrial diseases, Elemipretide for myopathy in general and deoxycytidine (dC) + deoxythymidine (dT) for TK2 deficiency. Gene therapy is a promise for future treatments. Physical conditioning was proved to improve mitochondrial myopathy symptoms.
11 Νοε 2023 · In this review, we summarize the cellular determinants of mitochondrial dysfunction, including impairment of electron transport chain complex 1, increased oxidative stress, disturbed mitochondrial quality control mechanisms, and cellular bioenergetic deficiency.
