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2 Σεπ 2024 · One of the possible mechanisms of action of citicoline is to modulate autophagy, a cellular process that regulates the degradation and recycling of damaged or unwanted components. Autophagy is essential for maintaining cellular homeostasis and preventing oxidative stress, inflammation, and apoptosis.
Neuroprotective activity of citicoline has been repeatedly shown in preclinical models of brain ischaemia and trauma, but two recent, large, pivotal clinical trials have revealed no benefits in ischaemic stroke and traumatic brain injury.
30 Σεπ 2018 · Recent Data at the Bench on Citicoline Background and Purpose —In this work, we review recent data on the actions of citicoline, citicoline is a drug with demonstrated neuroprotective properties in both animals and humans.
30 Νοε 2022 · This review is focused on the main indications of the drug, as acute stroke and its sequelae, including the cognitive impairment, and traumatic brain injury and its sequelae. There are retrieved the most important experimental and clinical data in both indications. Title: Citicolina: revisión farmacológica y clínica, actualización 2022.
12 Οκτ 2020 · The review found that citicoline has been proven to be a useful compound in preventing dementia progression. It also enhances cognitive functions among healthy individuals and improves prognosis after stroke.
2 Σεπ 2024 · This review aims to elucidate citicoline's anti-inflammatory mechanism and its clinical implications in conditions such as ischemic stroke, head trauma, glaucoma, and age-associated memory impairment.
8 Μαΐ 2024 · Despite heterogeneity and potential publication bias, consistent findings suggest Citicoline as a valuable adjunctive therapy, emphasizing the need for further research to refine its role in stroke management.
