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This is the first in a series of two articles that will outline the basic concepts of cancer genetics, including gene expres-sion, epigenetics and genetic variation. The second article [1] discusses genetic changes in malignancy and the emerging clinical applications of genomics.
A concise guide to understanding the genes that cause cancer; Update includes cancer-immune system interactions, technologies for DNA sequencing & analysis, liquid biopsies, and more; Relates cancer genes to the hallmark characteristics of the cancer cell and the clinical management of cancer
With 50% new material, including two new chapters on genetic analysis of cancer and cancer chemotherapy, improved pedagogy, examples of revolutionising technologies in drug design and delivery, and useful online resources, this textbook offers an accessible and engaging account of cancer biology for under-graduate and graduate students.
2 Οκτ 2024 · Molecular profiling enables clinicians to identify specific genetic abnormalities involved in cancer development. This knowledge is essential for selecting targeted therapies that disrupt critical tumor growth and survival pathways.
1 Μαΐ 2010 · Cancer is a genetic disease, arising as a result of a number of genetic alterations accumulating in stepwise manner within the cell, leading to uncontrolled proliferation and selection of those clones that acquire a growth advantage over their neighbouring cells.
22 Μαρ 2019 · Cellular and Molecular Basis of Cancer - Etiology, pathophysiology, symptoms, signs, diagnosis & prognosis from the Merck Manuals - Medical Professional Version.
This textbook, by leading experts at Massachusetts General Hospital Cancer Center, highlights the current understanding of the genetics of hereditary cancers of the breast, ovary, colorectum, stomach, pancreas, kidney, skin, and endocrine organs.
