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Before cleavage by caspase 1, pro-IL-1β has a molecular weight of 37 kDa. [13] The molecular weight of the proteolytically processed IL-1β is 17.5 kDa. IL-1β has the following amino acid sequence:
29 Αυγ 2010 · Here we present the crystal structure of IL-1β bound to IL-1 receptor type II (IL-1RII) and IL-1RAcP. IL-1β–IL-1RII generated a composite binding surface to recruit IL-1RAcP.
18 Σεπ 2009 · Interleukin-1β (IL-1β) is a master cytokine involved in initiating the innate immune response in vertebrates (Dinarello, C. A. (1994) FASEB J. 8, 1314–1325). It is first synthesized as an inactive 269-residue precursor (pro-interleukin-1β or pro-IL-1β). Pro-IL-1β requires processing by caspase-1 to generate the active, mature 153-residue cytokine.
18 Ιαν 2010 · Key Points. The interleukin-1 (IL-1) cytokine family comprises 11 members: IL-1α, IL-1β, IL-1 receptor antagonist (IL-1Ra), IL-18, IL-33 and IL-1F5–IL-1F10. The biology of IL-1F5–IL-1F10 is...
The crystal structure of recombinant human interleukin-1 beta (IL-1 beta) has been determined at 2.0 A resolution and refined to a crystallographic R-factor of 0.19. Three heavy-atom derivatives were identified and used for multiple isomorphous replacement phasing.
6 Ιουν 2019 · Molecular mechanism of interleukin-1 activation. There are two individual forms of IL-1, IL-1α and IL-1β, isolated from two distinct cDNAs, but they are indistinguishable in terms of their biological functions .
19 Ιουν 2019 · Structural biology has added a wealth of information to the molecular mechanisms of IL-1 family signaling. To date, three high-resolution ternary complexes have been determined by X-ray crystallography: IL-1β/IL-1R1/IL-1RAcP, IL-33/ST2/IL-1RAcP, and Il-18/IL-18Rα/IL-18Rβ.
