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Before cleavage by caspase 1, pro-IL-1β has a molecular weight of 37 kDa. [13] The molecular weight of the proteolytically processed IL-1β is 17.5 kDa. IL-1β has the following amino acid sequence:
18 Ιαν 2010 · This Review provides a comprehensive and contemporary overview of the interleukin-1 (IL-1) family: their expression and regulation, their effects on innate immune cells, their regulation of...
6 Ιουν 2019 · Molecular mechanism of interleukin-1 activation. There are two individual forms of IL-1, IL-1α and IL-1β, isolated from two distinct cDNAs, but they are indistinguishable in terms of their biological functions .
29 Αυγ 2010 · Interleukin 1β (IL-1β) is a key orchestrator of inflammation and host defense that exerts its effects through IL-1 receptor type I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). How...
21 Μαρ 2016 · The IL-1 cytokine family comprises 11 members (7 ligands with agonist activity, 3 receptor antagonists and 1 anti-inflammatory cytokine) and is recognised as a key mediator of inflammation and fibrosis in multiple tissues including the lung.
1 Αυγ 2011 · Pro-IL-1β is cleaved by the pro-inflammatory protease caspase-1 [3]. The activation of caspase-1 occurs via recruitment to a multi-protein complex termed the inflammasome (Fig. 1 A); a molecular scaffold composed of adaptor molecules, a cytosolic pattern recognition receptor, and pro-caspase-1 [4].
Molecular weight. 17 kDa. Class. Recombinant. Type. Protein.
