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12 Φεβ 2024 · In patients with arrhythmias and cardiovascular instability, sodium bicarbonate can be administered to adults with 4 to 8-hour IV infusions.
31 Αυγ 2021 · The rationale for using sodium bicarbonate for metabolic acidosis is that the intravenous administration of a high SID solution would increase the pH, resulting in improved cardiac function. The evidence on the biochemical effects of intravenous sodium bicarbonate in acute metabolic acidosis has been systematically reviewed [ 23 ].
18 Οκτ 2018 · Although far from definitive, this study supports treating severe metabolic acidemia (largely caused by lactic acidosis) with intravenous sodium bicarbonate solution, particularly in patients with advanced AKI.
As Sodium bicarbonate 8.4% has a very high osmolarity and ideally should only be given via a central line, it may occasionally be necessary to dilute this strength. However, it is preferable to use a premade infusion bag containing 1.26% sodium bicarbonate.
Direct IV infusion for emergencies (eg, cardiac arrest): Rapid IV dose of 1-2 vials of 50 mL (44.6-100 mEq) initially and continued at a rate of 50 mL (44.6 to 50 mEq) every 5-10 minutes...
Sodium bicarbonate may be administered if there is a concern for the suppressed cardiac function that metabolic acidosis may cause. The rationale for using sodium bicarbonate for metabolic acidosis is that the intravenous administration of a high SID solution would increase the pH, resulting in improved cardiac function.
15 Αυγ 2019 · The BICAR-ICU study compared intravenous administration of 4.2% sodium bicarbonate (q.s. pH > 7.30) with a control arm without infusion of bicarbonate in patients with severe metabolic acidosis (pH ≤ 7.20, bicarbonate < 20 mmol/L and PaCO 2 ≤ 45 mmHg) and a SOFA score ≥ 4 or arterial blood lactate ≥ 2 mmol/L. This randomized, controlled ...
