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Narrow therapeutic index (NTI) drugs are defined as those drugs where small differences in dose or blood concentration may lead to dose and blood concentration dependent, serious therapeutic failures or adverse drug reactions.
4 Αυγ 2021 · In the proposed definition above, Narrow Therapeutic Index drugs are those that are subject to therapeutic drug monitoring (TDM) based on pharmacokinetic (PK) or pharmacodynamic (PD) measures.
The therapeutic index (TI) is the range of doses at which a medication is effective without unacceptable adverse events. Drugs with a narrow TI (NTIDs) have a narrow window between their effective doses and those at which they produce adverse toxic effects.
7 Σεπ 2021 · Objectives: Historically, the identification of drugs with the Narrow Therapeutic Index (NTI) has been empirically based on the clinical practice. In general terms, NTI drugs can be defined based on the steepness of the dose-response relationship and the degree of overlap between the effective and the toxic concentrations.
4 Ιαν 2023 · Purpose: Narrow therapeutic index (NTI) drugs must be routinely monitored for their severe effects. These drugs share some common features and criteria that focus on the separation of safety and efficacy in relation to toxicity and efficacy.
Drugs with a narrow therapeutic index have a small therapeutic window, meaning minor fluctuations in serum concentrations may have profound effects on efficacy, or lead to unacceptable adverse effects and/or toxicity. If available, therapeutic drug monitoring is advised or required for narrow therapeutic index drugs.
