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The prime targets of lead toxicity are the multipotent neural stem cells (NSCs). The present review will discuss the basic molecular physiology involved in the toxicity mechanisms induced by lead and its resultant counter effects on nervous system and physiology.
The prime targets of lead toxicity are the multipotent neural stem cells (NSCs). The present review will discuss the basic molecular physiology involved in the toxicity mechanisms induced by lead and its resultant counter effects on nervous system and physiology.
1 Ιουν 2024 · Model of neural development by differentiating human induced pluripotent stem cells into neural progenitor cells to study the neurodevelopmental toxicity of lead
1 Μαρ 2019 · We examined the effect of lead toxicity on P19 stem cell determination into NPCs using Retinoic acid. We found that lead has an adverse effect on both the number of neurospheres formed and their mean diameter.
1 Σεπ 2023 · Lead (Pb) exposure causes immeasurable damage to multiple human systems, particularly the central nervous system (CNS). In this study, human induced pluripotent stem cells (hiPSCs) were differentiated into neural progenitor cells (NPCs) to investigate the neurotoxic effects of Pb.
21 Ιουλ 2021 · Notably, although the central nervous system is particularly susceptible to Pb 2+, other systems are affected as well. The present study focuses on molecular mechanisms that underlie the effects that arise from the presence of Pb 2+ in situ in the brain, and the possible toxic effects that follows.
1 Μαΐ 2014 · Here, we investigated the effects of physiologically relevant concentrations of Pb (from 0.4 to 1.9μM) on the capacity of human embryonic stem cells (hESCs) to progress to a neuronal fate. We found that neither acute nor chronic exposure to Pb prevented hESCs from generating neural progenitor cells (NPCs).
