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  1. 12 Οκτ 2020 · With the goal of developing a new class of anticoagulants associated with a lower risk of bleeding than currently available agents, dozens of drugs targeting the contact system are now in development.

  2. 18 Οκτ 2024 · Over the last decade, the advent of direct oral anticoagulants (DOACs) has rapidly changed the landscape of anticoagulation. In the early 2010s, DOACs became widely available for stroke prevention in atrial fibrillation and the treatment of venous thromboembolism.

  3. 25 Φεβ 2015 · This review discusses the new anticoagulants such as dabigatran, edoxaban, rivaroxaban, and apixaban, and provides practical and easy-to-use algorithms for application in the clinical routine specially focused on AF prophylaxis.

  4. 29 Απρ 2016 · Thromboembolism involving the arterial or venous circulation is the most common cause of morbidity and mortality worldwide. 1 Anticoagulation therapy is a cornerstone of thromboembolism prevention and treatment. Vitamin K antagonists (VKAs) such as warfarin were the only orally administered anticoagulants for >60 years.

  5. 19 Μαρ 2015 · The non-vitamin K antagonist oral anticoagulants are already replacing low-molecular-weight heparin for thromboprophylaxis in patients undergoing elective hip or knee arthroplasty and replacing warfarin for stroke prevention in patients with atrial fibrillation and treatment of venous thromboembolism.

  6. 19 Ιουν 2014 · New oral anticoagulants (NOAC) are becoming available as alternatives to warfarin to prevent systemic embolism in patients with non-valvular atrial fibrillation and for the treatment and prevention of venous thromboembolism.

  7. The most likely treatments to reduce symptomatic venous thromboembolism compared with placebo were pentasaccharides (odds ratio 0.32, 95% credible interval 0.08 to 1.07; posterior probability of benefit 97%), intermediate dose low-molecular-weight heparin (0.66, 0.46 to 0.93; 99%), direct oral anticoagulants (0.68, 0.33 to 1.34; 88%), and ...

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