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  1. 7 Νοε 2022 · Currently, survival rates exceed 90% in HER2 + early breast cancer (EBC) treated with chemotherapy and dual antibody therapy 5.

  2. 9 Μαρ 2022 · First-line therapy with ribociclib plus letrozole showed a significant overall survival benefit as compared with placebo plus letrozole in patients with HR-positive, HER2-negative advanced breast...

  3. 8 Ιαν 2024 · Several trials have investigated different and novel HER2-targeted agents in cohorts of patients with previously treated metastatic HER2 + breast cancer. Among these new therapies, TKIs...

  4. 2 Ιουν 2024 · With a median progression-free survival of more than a year, the results from DESTINY-Breast06 show that Enhertu could become a new standard of care for patients with HER2-low- and HER2-ultralow-expressing tumours following endocrine therapy in the metastatic setting.”

  5. 18 Ιουν 2024 · Updated results from the phase 3 INAVO120 trial showed that adding inavolisib to palbociclib and fulvestrant can improve outcomes in patients with PIK3CA -mutated, HR-positive, HER2-negative...

  6. 11 Οκτ 2022 · The treatment landscape of HR+/HER2− advanced breast cancer is changing. New available therapies include amongst others mTOR inhibitors and CDK4/6 inhibitors. Phase 3 clinical trials on CDK4/6 inhibitors have all proved progression-free survival benefit.

  7. 2 Ιουν 2021 · Krop IE, Kim SB, Martin AG, et al: Trastuzumab emtansine versus treatment of physician's choice in patients with previously treated HER2-positive metastatic breast cancer (TH3RESA): Final overall survival results from a randomised open-label phase 3 trial.

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