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4 Απρ 2024 · We propose a new way of utilizing normal modes to study protein conformational transitions. Instead of considering individual modes independently, we show that a weighted mixture of low-frequency vibrational modes can reveal dynamic information about the conformational mechanism in more detail than any single mode can.
29 Νοε 2019 · As a result of normal mode analysis, the protein motion is represented as a linear combination of mutually independent normal mode vectors. It has been widely accepted that the large amplitude motions throughout the entire protein molecule can be well described with a few low-frequency normal modes.
10 Σεπ 2019 · Normal mode analysis (NMA) is a technique that can be used to describe the flexible states accessible to a protein about an equilibrium position. These states have been shown repeatedly to have functional significance.
22 Οκτ 2020 · Normal mode analysis is a technique, based on the physics of small oscillations, that can be used to describe the flexible states accessible to a protein around an equilibrium position. The idea is that when an oscillating system at equilibrium, for example a protein in an energy minimum conformation, is slightly perturbed, a restoring force ...
4 Φεβ 2024 · Normal mode analysis (NMA) has been a staple in studying protein dynamics since the early days of computational chemistry,1−8 rooted in infrared (IR) spectroscopy.9−13 Arguably the most important aspect of NMA is that the lowest-frequency normal modes exhibiting the largest ampli-tudes are often relevant to biological function.
19 Οκτ 2018 · Comprehensive analysis of physiologic amino acids in blood, urine, and cerebrospinal fluid is typically performed in the following clinical settings: evaluation of symptomatic patients in whom...
22 Οκτ 2020 · This study shows the feasibility of dynamic descriptors derived from normal mode analysis in elastic network models of HIV type 1 (HIV-1) protease in predicting drug resistance.
