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  1. 4 Σεπ 2019 · To date, pharmacological treatments and supplementation of individual nutrients have been poorly effective in terms of the prevention and treatment of AD, while alternative strategies based on multimodal approaches (diet, exercise, and cognitive training) seem to be more promising.

  2. 30 Οκτ 2022 · The application of the principles of rational nutrition for the elderly is suggested for Alzheimer’s disease. The diet should be rich in neuroprotective nutrients, i.e., antioxidants, B vitamins, and polyunsaturated fatty acids.

  3. Alzheimer’s disease (AD) is a disease caused by the complex interaction of multiple mechanisms, some of which are still not fully understood. To date, pharmacological treatments and supplementation of individual nutrients have been poorly effective in terms

  4. 30 Οκτ 2022 · Some studies suggest that diets such as the Mediterranean diet, the DASH (Dietary Approaches to Stop Hypertension) diet, and the MIND (Mediterranean-DASH Intervention for Neurodegenerative Delay) diet have a beneficial effect on the risk of developing Alzheimer's disease.

  5. This article reviews existing nutritional modalities for AD prevention that act through improvement of insulin resistance, correction of dyslipidemia, and reduction of oxidative stress, and discusses how they may be modified on the basis of individual biomarkers, genetics, and behavior.

  6. An ambitious feeding trial of the MIND diet (NCT02817074) is ongoing, aimed at preventing Alzheimer's disease in an at-risk population (ie, those with obesity, a family history of dementia, and a suboptimal diet). The trial's primary outcome is a change in global cognitive composite score with additional surrogate outcomes, including brain ...

  7. 20 Οκτ 2014 · Treatment with selegiline (15 mg twice daily) and α-tocopherol (1000 IU twice daily) increased median survival by 215 and 230 days over the placebo, respectively ( Sano et al., 1997 ). These findings led to widespread use of a daily dose of 2000 IU α-tocopherol to slow progression in AD.

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