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HK-2 is an immortalized human kidney epithelial cell line commonly used in toxicology research. Researchers evaluate the effects of environmental toxins on these kidney cells. In addition, they also employ HK-2 cells to investigate kidney diseases and their underlying mechanisms.
HK-2 cells retain functional characteristics of proximal tubular epithelium such as Na＋dependent/phlorizin sensitive sugar transport and adenylate cyclase responsiveness to parathyroid, but not to antidiuretic hormone.
The HK-2 cell line is a well-characterized human proximal tubular epithelial cell line derived from normal adult kidney tissue. These cells exhibit typical epithelial morphology and retain many of the biochemical and functional properties of proximal tub…
HK-2 (human kidney 2) is a proximal tubular cell (PTC) line derived from normal kidney. The cells were immortalized by transduction with human papilloma virus 16 (HPV-16) E6/E7 genes. The cell line appears to be derived from a single cell based on Southern and FISH analysis.
26 Σεπ 2023 · We investigated gene and protein expression of HK-2 cells cultured in six medium formulations. TGF-β1 increased the expression of ACTA2, TGFB1, COL4A1, EGR2, VIM and CTGF genes while reducing PPARG in all medium formulations.
10 Μαρ 2014 · Cytokine release assay comparing release of Il-6 (A), Il-8 (B) and MCP-1 (C) from HK-2 cells grown on KMS compared with HK-2 cells grown on plastic. The results include data for 1, 2, 3 and 4 weeks with no stimulation and following stimulation by Il-1α and TNF-α and a hypoxia challenge.
26 Σεπ 2023 · We investigated gene and protein expression of HK-2 cells cultured in six medium formulations. TGF-β1 increased the expression of ACTA2, TGFB1, COL4A1, EGR2, VIM and CTGF genes while reducing...
