Αποτελέσματα Αναζήτησης
26 Σεπ 2023 · Epithelial-to-mesenchymal transition (EMT) is the main pathological process of tubulointerstitial fibrosis in vitro. Transforming growth factor-beta (TGF-β) is a key inducer of EMT. Several pro-fibrotic gene expression differences have been observed in a TGF-β-induced EMT model of HK-2 cells.
HK-2 (human kidney 2) is a proximal tubular cell (PTC) line derived from normal kidney. The cells were immortalized by transduction with human papilloma virus 16 (HPV-16) E6/E7 genes. The cell line appears to be derived from a single cell based on Southern and FISH analysis.
20 Μαΐ 2019 · In the present study, we aimed to establish a HK-2 cell model for screening xanthine oxidase inhibitors, and explored the molecular basis of this cell model. This novel cell model has the potential for use in high-throughput screening systems for antihyperuricemic functional compounds.
1 Μαρ 2017 · In this manuscript, we demonstrate that the HK-2 cell is a viable model to study TFV-induced cytotoxicity at clinically relevant concentrations. Further, these studies revealed that oxidative stress, induction of apoptosis, and mitochondrial decline in ATP are associated with TFV renal cytotoxicity.
29 Ιουλ 2020 · One of the most widely used proximal tubule cell lines is the human kidney 2 (HK-2) cell line, which was established over 2 decades ago as a useful cellular tool for carrying out in vitro toxicology studies. 5-7 These cells have been shown to capture essential characteristics of human primary proximal tubules. This cell line is similar to its ...
1 Μαρ 2017 · In this manuscript, we demonstrate that the HK-2 cell is a viable model to study TFV-induced cytotoxicity at clinically relevant concentrations. Further, these studies revealed that oxidative stress, induction of apoptosis, and mitochondrial decline in ATP are associated with TFV renal cytotoxicity. 2. Results.
29 Απρ 2019 · The effects of Ang II (Lot: A9290, Solarbio) treatment on HK-2 cell viability were evaluated using the Cell Counting Kit-8 colorimetric assay (Lot: KH741, Dojindo). Briefly, HK-2 cells were seeded at a density of 5 × 10 3 cells/well (in 100 μL culture medium) in a 96-well plate.
