Αποτελέσματα Αναζήτησης
27 Ιουν 2022 · This review aims to provide a brief overview of DKA from its pathophysiology to clinical presentation with in depth focus on up-to-date therapeutic management.
Cerebral edema is a condition of excess of fluid in the brain resulting from either neurological or non-neurological causes. Cerebral edema can result from a variety of mechanisms. These include cellular, vasogenic, interstitial, and osmotic mechanisms.
The pathophysiological mechanisms for cerebral edema associated with DKA occuring in children and adults are believed to be similar and are discussed in this report, however, patients who develop cerebralEdema may deteriorate rapidly, and experience with successful treatment has been limited.
Cerebral edema manifests clinically in approximately 1% of DKA patients with progression to brain herniation, representing the major cause of mortality and morbidity in DKA [4]. However, asymptomatic or subclinical cerebral edema, as detected by subtle brain computed tomography (CT) or magnetic resonance imaging (MRI)
Cerebral edema is described as occurring in DKA in 0.4 to nearly 5% of cases, due to referral bias and variable diagnostic criteria. Mortality in the context of cerebral edema is 21% with morbidity rates reported of 10-26%.
Cerebral edema is the most serious complication of DKA, with a mortality rate of 20–40%. 1 It develops in up to 1% of pediatric DKA cases in individuals younger than 20 years of age. However, little is known about DKA in adults. Here, we report two cases of DKA‐induced cerebral edema.
Objective: To review the causes of cerebral edema in diabetic ketoacidosis (CEDKA), including pathophysiology, risk factors, and proposed mechanisms, to review the diagnosis, treatment, and prognosis of CEDKA and the treatment of diabetic ketoacidosis as it pertains to prevention of cerebral edema. Data source: A MEDLINE search using OVID was ...
