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Cerebral edema is a condition of excess of fluid in the brain resulting from either neurological or non-neurological causes. Cerebral edema can result from a variety of mechanisms. These include cellular, vasogenic, interstitial, and osmotic mechanisms.
Fourth, data suggest that the predominant pathophysiology early after initial cerebral injury (broadly defined) is cerebral ischemia, followed in the subacute stages by a more vasogenic process. Finally, impaired cerebral autoregulation is documented in both TBI and DKA, either reflecting the disease severity or playing a role in the ...
Symptomatic cerebral edema (CE) in pediatric patients with DKA is uncommon and is defined by diagnostic criteria, including abnormal motor or verbal responses to pain, decorticate posture, and abnormal neurogenic respiratory patterns.
cerebral edema, as detected by subtle brain computed tomography (CT) or magnetic resonance imaging (MRI) changes, can occur in as much of 50% of DKA patients. Hence, early identification of clinically relevant cerebral edema in DKA relies on clinical criteria rather than solely on radiological tests [5]. Clinical identification of
Cerebral edema is described as occurring in DKA in 0.4 to nearly 5% of cases, due to referral bias and variable diagnostic criteria. Mortality in the context of cerebral edema is 21% with morbidity rates reported of 10-26%.
Objective: To review the causes of cerebral edema in diabetic ketoacidosis (CEDKA), including pathophysiology, risk factors, and proposed mechanisms, to review the diagnosis, treatment, and prognosis of CEDKA and the treatment of diabetic ketoacidosis as it pertains to prevention of cerebral edema. Data source: A MEDLINE search using OVID was ...
1 Φεβ 2000 · In the absence of empiric clinical data to definitively implicate fluid therapy as the cause of cerebral edema in DKA, many have turned to established physiological principles to explain the disease.
