Αποτελέσματα Αναζήτησης
17 Αυγ 2022 · Subclinical cerebral edema, as detected by ventricular narrowing on imaging studies or alterations in brain water distribution on magnetic resonance imaging (MRI), has been reported in the majority of children with DKA, even in the absence of neurologic signs or symptoms (image 1) [6,15,16].
Cerebral edema (CE) is a potentially devastating complication of diabetic ketoacidosis (DKA) that almost exclusively occurs in children. Since its first description in 1936, numerous risk factors have been identified; however, there continues to be ...
This review critically examines the literature on the pathophysiology of CE and attempts to categorize the findings by types of brain injury that contribute to its development: cytotoxic, vasogenic, and osmotic.
Fourth, data suggest that the predominant pathophysiology early after initial cerebral injury (broadly defined) is cerebral ischemia, followed in the subacute stages by a more vasogenic process.
The study highlights that while head CT is obtained to diagnose cerebral edema, decisions about treatment of patients with DKA and suspected CE are not affected by head CT results and, in-fact, obtaining a head CT may have led to a significant delay in hyperosmolar therapy.
1 Φεβ 2000 · Among the most attractive features of a hypothesis implicating cerebral hypoxia in the pathogenesis of DKA-associated cerebral edema is the high oxygen requirement of children’s brains (3.3 mL/100g·min in adults, 5.1 mL/100g·min in children) (44).
18 Δεκ 2018 · Treatment of cerebral edema in DKA with hyperosmolar agents is recommended as the pathophysiology of cerebral edema is not very well understood.6, 16, 17, 18, 19 An ischemic6 and/or vasogenic18 process is proposed to play a role in the genesis of DKA related cerebral edema.
