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3 Σεπ 2024 · Pharmacologic treatment of alcohol use disorder has focused on altering the reinforcing effects of alcohol use. Medication development has focused on several neurotransmitter systems that mediate reinforcement including opioid, glutamate, gamma-aminobutyric acid, and serotonin systems.
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Stephen R Holt, MD, MS, FACP Disclosure: No relevant...
- Christensen C. Management of Chemical Dependence in Pregnancy. Clin Obstet Gynecol 2008; 51:445
College student receptiveness to various alcohol treatment...
- Skinner Md, Lahmek P, Pham H, Aubin Hj. Disulfiram Efficacy in The Treatment of Alcohol Dependence: a Meta-Analysis. PLoS One 2014; 9:E87366
The primary outcome was 90-day alcohol-related hospital...
- Anton Rf, Latham P, Voronin K, Et Al. Efficacy of Gabapentin for The Treatment of Alcohol Use Disorder in Patients With Alcohol Withdrawal Symptoms: a Randomized Clinical Trial. JAMA Intern Med 2020; 180:728
A meta-analysis of the efficacy of gabapentin for treating...
- Kranzler Hr, Feinn R, Morris P, Hartwell Ee. a Meta-Analysis of The Efficacy of Gabapentin for Treating Alcohol Use Disorder. Addiction 2019; 114:1547
METHODS One hundred and thirteen participants meeting DSM IV...
- Hartung Dm, McCarty D, Fu R, Et Al. Extended-release Naltrexone for Alcohol and Opioid Dependence: a Meta-Analysis of Healthcare Utilization Studies. J Subst Abuse Treat 2014; 47:113
Medline ® Abstract for Reference 7 of 'Alcohol use disorder:...
- De Bejczy A, Löf E, Walther L, Et Al. Varenicline for Treatment of Alcohol Dependence: a Randomized, Placebo-Controlled Trial. Alcohol Clin Exp Res 2015; 39:2189
CONCLUSION Our results question baclofen's utility in the...
- GBD 2016 Alcohol and Drug Use Collaborators. The Global Burden of Disease Attributable to Alcohol and Drug Use in 195 Countries and Territories, 1990-2016: a Systematic Analysis for The Global Burden of Disease Study 2016. Lancet Psychiatry 2018; 5:987
FINDINGS Globally, alcohol use disorders were the most...
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5 Νοε 2022 · Alcohol (ethanol) is a central nervous system (CNS) depressant drug that, depending on its blood concentration, can induce various manifestations such as relief from anxiety, disinhibition, ataxia, and general anesthesia. Chronic exposure to alcohol can cause...
20 Μαΐ 2020 · The FDA has approved three medications for alcohol use disorder: naltrexone, acamprosate, and disulfiram. Additionally, other medications including gabapentin, baclofen, topiramate, and ondansetron show promise off-label for treating alcohol use disorder.
23 Ιαν 2014 · Pharmacologic strategies for treating alcohol dependence include generating an aversive physiological reaction to alcohol to mask positive subjective effects and administering medications that block alcohol reinforcement.
21 Αυγ 2014 · Clinical Points. Alcohol use disorder is a complex disease affecting 18 million people in the United States; its pathophysiology is driven by the mesolimbic dopaminergic system.
The FDA-approved medications and others undergoing pre-clinical and clinical trials are shown. The inhibitory effects of alcohol intake are mediated through the hormone ghrelin, oxytocin and opioid receptors, that are expressed in VTA, NAc, hypothalamus and amygdala of the brain.
Abstract. Alcohol use disorder (AUD) is commonly encountered in clinical practice. A combination of psychosocial intervention and pharmacotherapy is the cornerstone of AUD treatment. Despite their efficacy, safety and cost-effectiveness, clinicians are reluctant to prescribe medications to treat individuals with AUD.
