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1 Ιουλ 2014 · Alcohol’s effects on neurological function and disease are carried out through the actions of a variety of brain neurotransmitters, where there is a complex interplay between excitatory and inhibitory systems. Alcohol, consistent with a variety of other drugs of abuse, increases dopamine levels.
Alcohol interferes with the brain’s communication pathways and can affect the way the brain looks and works. Alcohol makes it harder for the brain areas controlling balance, memory, speech, and judgment to do their jobs, resulting in a higher likelihood of injuries and other negative outcomes.
Investigators use a variety of methods to study alcoholism-related brain damage, including examining brains of deceased patients as well as neuroimaging, a technique that enables researchers to test and observe the living brain and to evaluate structural damage in the brain.
Well-supported scientific evidence shows that disruptions in three areas of the brain are particularly important in the onset, development, and maintenance of substance use disorders: the basal ganglia, the extended amygdala, and the prefrontal cortex.
1 Δεκ 2021 · We discuss seven distinct but tightly interlinked levels of effects of alcohol on the brain, starting from genetic factors that confer susceptibility to AUD (level 1), through alcohol-induced changes in epigenetic mechanisms (level 2), transcriptional activity (level 3), alternative splicing (level 4), translation (level 5), and post ...
Alcohol-induced changes in brain functions can lead to disordered cognitive functioning, disrupted emotions and behavioral changes. Moreover, these brain changes are important contributing factors to the development of alcohol use disorders, including acute intoxication, long-term misuse and dependence.
The focus of the field is now on pinpointing which molecular effects in specific neurons within a brain region contribute to behavioral changes across the course of acute and chronic ethanol exposure. Keywords. ethanol. withdrawal. intoxication. dependence. alcoholism. addiction. synaptic transmission. synaptic plasticity. neuroadaptation.
