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Polysorbates include oleic acid (Polysorbate-80), lauric acid (Polysorbate-20), and stearic acid (Polysorbate-60). These all appear to be immunologically cross reactive with polyethylene gylcols. The Stone and coworkers article noted below has the skin testing methodology well described.
An allergic reaction to PEG should be suspected in patients with (5,17,28) systemic HRs to laxatives or bowel preparations; to only certain brand names or doses of the same drug; following invasive procedures or during operations; to PEG containing products or PEGylated drugs where hypersensitivity to the active drug is excluded; to a PEG ...
Skin testing and oral challenges with PEG and polysorbate-containing agents were employed to determine clinical reactivity and cross-reactivity between the 2 allergens. Enzyme-linked immunosorbent assay and electrochemiluminescent immunoassay were used to detect anti-PEG specific IgG and IgE, respectively, using PEGylated protein or PEG alone ...
International guidelines suggested skin tests with Polyethylene-glycol (PEG) and polysorbate 80 (PS-80), to investigate a possible hypersensitivity to these excipients either to identify subjects at risk of developing allergic reactions to Covid-19 vaccines, or in patients with suspected IgE mediated hypersensitivity reactions (HR) to the Covid ...
We evaluated skin prick test (SPT) results and in vitro reactivity over time to different MW PEGs and assessed cross-sensitization patterns in PEG allergy. Ten patients with previously diagnosed PEG allergy underwent SPT twice with PEGs 26 months apart.
28 Απρ 2023 · Allergometric skin tests for PEG and PS80 in our case series resulted positive in an unexpectedly high proportion of patients, suggesting that testing for allergy to these two excipients should not be ignored in case of reasonable clinical suspicion.
Our results suggest that skin testing for PEG and PS after a suspected allergic reaction to a COVID-19 vaccine has limited use and there are likely other explanations for some reactions that are not PEG IgE-mediated reactions.
