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Autoimmune neutropenia (AIN) is a blood disorder where your immune system attacks white blood cells (neutrophils) that fight infection. AIN may be primary or secondary.
2 Δεκ 2016 · This educational review addresses the diagnostic evaluation of patients for autoimmune and other forms of acquired neutropenia, including the futility of deconstructing the overlap of chronic “autoimmune,” “benign,” and “idiopathic” categories.
21 Αυγ 2014 · Primary autoimmune neutropenia usually occurs during the first year of life. As the name implies, it manifests without other signs or symptoms of an underlying autoimmune disorder. 46 Neutropenia can be moderate to severe and complicated by serious infections.
15 Ιαν 2023 · Autoimmune neutropenia (AIN) is a reduced number of neutrophils resulting from increased peripheral destruction by antineutrophil antibodies from autoimmune disorders.[1] These autoantibodies are directed against cell membrane antigens present on IgG Fc receptors.[2]
9 Απρ 2024 · Primary autoimmune neutropenia in infancy is the most common cause of neutropenia in children <2 years old. Berliner N, Horwitz M, Loughran TP Jr. Congenital and acquired neutropenia.
In autoimmune neutropenia, the immune system produces autoantibodies directed against the neutrophilic protein antigens in white blood cells known as granulocytic neutrophils, granulocytes, segmented neutrophils, segs, polysegmented neutrophils, or polys.
10 Δεκ 2021 · Disorders such as primary autoimmune neutropenia and chronic idiopathic neutropenia typically have adequate bone marrow storage pools of neutrophils to respond to infection and therefore present a low risk for SBIs.
