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10 Δεκ 2021 · Common medical quandaries including fever management, need for growth factor support, risk of malignant transformation, and curative options in congenital neutropenia are reviewed to guide medical decision-making in neutropenic patients.
- How we evaluate and treat neutropenia in adults
Primary autoimmune neutropenia usually occurs during the...
- Autoimmune and other acquired neutropenias | Hematology, ASH Education ...
This educational review addresses the diagnostic evaluation...
- How we evaluate and treat neutropenia in adults
21 Αυγ 2014 · Primary autoimmune neutropenia usually occurs during the first year of life. As the name implies, it manifests without other signs or symptoms of an underlying autoimmune disorder. 46 Neutropenia can be moderate to severe and complicated by serious infections.
27 Απρ 2023 · Five main topics were identified: (1) definition and classification of neutropenias, (2) diagnostic approach, (3) natural history and follow-up, (4) treatment, and (5) special situations, and a number of key questions were formulated for each topic.
2 Δεκ 2016 · This educational review addresses the diagnostic evaluation of patients for autoimmune and other forms of acquired neutropenia, including the futility of deconstructing the overlap of chronic “autoimmune,” “benign,” and “idiopathic” categories.
Autoimmune neutropenias (AIN) are often defined by a reduction of the absolute peripheral blood (PB) neutrophil count (ANC) below the reference values for age 4–7 ( Table 1) together with the demonstration of autoantibodies against human neutrophil antigens (HNAs) ( Figure 1 ). 8–13 In addition to humoral immunity, that is, autoantibodies, cellu...
Primary AIN is more prevalent in children, generally self-limited, and typically manifests as a sole hematologic abnormality. Secondary AIN is more common in adults and often occurs in the setting of concurrent autoimmune diseases, infections, malignancies, or medications.
8 Δεκ 2014 · Autoimmune neutropenia of infancy (AIN), also called primary autoimmune neutropenia, is a disease in which antibodies recognize membrane antigens of neutrophils, mostly located on immunoglobulin G (IgG) Fc receptor type 3b (FcγIIIb receptor), causing their peripheral destruction.
