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10 Δεκ 2021 · Establishing the correct diagnosis and differentiating benign vs severe pathologic mechanisms of neutropenia are critical to inform medical decision-making regarding infectious risk, the utility of supportive care measures, the possibility of malignant transformation, and curative approaches.
27 Απρ 2023 · Five main topics were identified: (1) definition and classification of neutropenias, (2) diagnostic approach, (3) natural history and follow-up, (4) treatment, and (5) special situations, and a number of key questions were formulated for each topic.
21 Αυγ 2014 · Primary autoimmune neutropenia usually occurs during the first year of life. As the name implies, it manifests without other signs or symptoms of an underlying autoimmune disorder. 46 Neutropenia can be moderate to severe and complicated by serious infections.
2 Δεκ 2016 · This educational review addresses the diagnostic evaluation of patients for autoimmune and other forms of acquired neutropenia, including the futility of deconstructing the overlap of chronic “autoimmune,” “benign,” and “idiopathic” categories.
The most common primary immune deficiencies (PIDs) associated with NP are X-linked agammaglobulinemia, hyper-IgM syndrome and WHIM syndrome, which are usually diagnosed early in life . In these disorders myelopoiesis is either suppressed due to defective intrinsic mechanisms of maturation or shows a poor/absent egress of mature cells from the ...
Primary AIN is more prevalent in children, generally self-limited, and typically manifests as a sole hematologic abnormality. Secondary AIN is more common in adults and often occurs in the setting of concurrent autoimmune diseases, infections, malignancies, or medications.
8 Δεκ 2014 · Autoimmune neutropenia of infancy (AIN), also called primary autoimmune neutropenia, is a disease in which antibodies recognize membrane antigens of neutrophils, mostly located on immunoglobulin G (IgG) Fc receptor type 3b (FcγIIIb receptor), causing their peripheral destruction.
