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An exacerbation of absences seizure was described in a woman with generalized epilepsy treated with progesterone for eleven years (Grunewald 1992) . One patient achieved seizure freedom while on treatment with progesterone but had a relapse after treatment with a reductase inhibitor (finasteride) (Herzog 2003) .
For patients taking both AEDs and HCs, the levels of serum progesterone and estrogen can be reduced if hepatic enzyme-inducing AEDs (EIAED) are used. Non-EIAEDs do not cause a reduction in hormone levels of the HC and therefore do not pose a risk in decreased HC efficacy (see Table 1 ).
Current treatment practices include the use of pulsed hormonal (e.g. progesterone) and non‐hormonal treatments (e.g. clobazam or acetazolamide) in women with regular menses, and complete cessation of menstruation using synthetic hormones (e.g. medroxyprogesterone (Depo‐Provera) or gonadotropin‐releasing hormone (GnRH) analogues (triptorelin and ...
Progesterone combined with antiepileptic therapy was well tolerated and resulted in a significant reduction of seizure frequency in majority of patients with catamenial epilepsy.
The main outcome included the efficacy of progesterone and its derivatives on seizure frequency. Results: Nineteen articles (457 patients) were included; four were randomized controlled trials (two comparing progesterone vs placebo and two comparing norethisterone vs placebo). Progesterone was generally administered during the luteal phase ...
Overall, progesterone appears to have anti-seizure effects, and seizure susceptibility is inversely correlated to its serum levels. These findings provide the rationale for investigating the efficacy of proges-terone, and especially AP, for the treatment of CE. 1.2. Progesterone levels in different stages of the menstrual cycle in
1 Ιαν 2013 · Progesterone with its anti-seizure effect plays a role in the pathophysiology of catamenial epilepsy which affects 31–60% of epileptic women. In this study, an attempt to treat women suffering from catamenial epilepsy with progesterone, as an adjuvant drug, was made.
