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  1. BlastP simply compares a protein query to a protein database. PSI-BLAST allows the user to build a PSSM (position-specific scoring matrix) using the results of the first BlastP run. PHI-BLAST performs the search but limits alignments to those that match a pattern in the query.

  2. The Basic Local Alignment Search Tool (BLAST) finds regions of local similarity between protein or nucleotide sequences. The program compares nucleotide or protein sequences to sequence in a database and calculates the statistical significance of the matches.

  3. 17 Νοε 2014 · DIAMOND is a high-throughput alignment program that compares a file of DNA sequencing reads against a file of protein reference sequences, such as NCBI-nr 19 or KEGG 3. It is implemented in C++...

  4. The Basic Local Alignment Search Tool (BLAST) finds regions of local similarity between sequences. The program compares nucleotide or protein sequences to sequence databases and calculates the statistical significance of matches.

  5. 7 Απρ 2021 · DIAMOND is a fast and sensitive protein aligner that was initially developed for metagenomics applications to achieve ultra-fast alignments at the cost of alignment sensitivity, compared with the...

  6. 7 Σεπ 2023 · Once structurally similar proteins have been identified, DeepBLAST can structurally align proteins using only sequence information by identifying structurally homologous regions between...

  7. The alignment of sequencing reads against a protein reference database is a major computational bottleneck in metagenomics and data-intensive evolutionary projects. Although recent tools offer improved performance over the gold standard BLASTX, they exhibit only a modest speedup or low sensitivity. …

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