Αποτελέσματα Αναζήτησης
1 Νοε 2012 · To assess the contributions that these 2 intermediates make to prothrombin activation in tissue factor (Tf)–activated blood, immunoassays were developed that measure the meizothrombin antithrombin (mTAT) and α-thrombin antithrombin (αTAT) complexes.
13 Φεβ 2018 · Prothrombin, or clotting factor II, is a modular protein composed of 579 amino acids organized into the Gla domain (residues 1–46), kringle-1 (residues 65–143), kringle-2 (residues 170–248), and...
16 Απρ 2019 · Prothrombin, or coagulation factor II, is a multidomain zymogen precursor of thrombin that undergoes an allosteric equilibrium between two alternative conformations, open and closed, that react...
2 Οκτ 2018 · Coagulation factor II, or prothrombin, is a multi-domain glycoprotein that is essential for life and a key target of anticoagulant therapy. In plasma, prothrombin circulates in two forms at equilibrium, "closed" (~80%) and "open" (~20%), brokered by the flexibility of the linker regions.
1 Οκτ 2018 · In response to vascular injury, coagulation factor II (FII), or prothrombin, is converted to its active form thrombin by prothrombinase, a macromolecular complex composed of factor Xa (fXa), factor Va (fVa), calcium ions, and phospholipids (1).
30 Ιουν 2013 · Thrombin is produced by proteolytic activation of the precursor, prothrombin, in the first committed step of the pathway to thrombus formation. Thrombin catalyzes thrombus formation and also a series of reactions that both positively and negatively regulate flux through the coagulation cascade.
3 Φεβ 2011 · Human prothrombin consists of fragment 1 (F1), fragment 2 (F2), and the A and B chains of α-thrombin. Prothrombin is activated to α-thrombin by cleavage at Arg271 (R 271) and Arg320 (R 320 ). Initial cleavage at Arg271 (left pathway) generates fragment 1.2 and the inactive intermediate prethrombin-2.
