Αποτελέσματα Αναζήτησης
1 Νοε 2012 · Prothrombin activation by prothrombinase (IIase or factor Xa [fXa]·fVa) involves cleavage at Arg271 and Arg320 to produce the α-thrombin (αIIa) product. 1,2 Depending on the order of cleavage, activation occurs via 2 possible intermediates; meizothrombin (mIIa) or prethrombin-2. mIIa arises from initial cleavage at Arg320, yielding a ...
16 Απρ 2019 · Prothrombin, or coagulation factor II, is a multidomain zymogen precursor of thrombin that undergoes an allosteric equilibrium between two alternative conformations, open and closed, that react...
3 Φεβ 2011 · Abstract. Effective hemostasis relies on the timely formation of α-thrombin via prothrombinase, a Ca 2+ -dependent complex of factors Va and Xa assembled on the activated platelet surface, which cleaves prothrombin at Arg271 and Arg320.
The enzyme complex cleaves the zymogen, prothrombin (II) at two sites to produce thrombin (IIa), which is composed of two chains in disulfide linkage and the release of the N‐terminal propiece fragment 1.2 (F12).
8 Αυγ 2016 · In vitro thrombin generation (TG) is a test that probes the capacity of blood (plasma) to form thrombin. A completely normal person with a provoked thrombosis will show signs of in vivo increased thrombin generation while their capacity to form thrombin may be normal.
9 Νοε 2012 · Results: Platelet-associated prothrombinase utilizes the prethrombin-2 pathway of prothrombin activation and a concerted enzyme mechanism. Conclusion: Platelet-associated prothrombinase activates prothrombin with a concerted mechanism in which no anticoagulant intermediates are released.
When prothrombinase is assembled on synthetic phospholipid vesicles, prothrombin activation proceeds with an initial cleavage at Arg-320 yielding the catalytically active, yet effectively anticoagulant intermediate meizothrombin, which is released from the enzyme complex ∼30–40% of the time.
