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26 Αυγ 2005 · Prothrombin differs from these proteins in that it contains two kringle domains (KR) in place of the two EGF-like domains. Moreover, prothrombin contains a tetradecapeptide loop structure between the Gla domain and the first KR.
8 Ιουν 2024 · Higher PT values indicate a prolonged clotting time, suggesting potential issues with clotting factors such as fibrinogen, factor V, VII, X, and prothrombin. Abnormal PT values may indicate liver disease, vitamin K deficiency, or the presence of anticoagulants.
Evidence that Proaccelerin Is Converted to a Prothrombin-converting Principle by Activated Stuart Factor: With Notes on the Anticoagulant Action of Soybean Trypsin Inhibitor, Protamine Sulfate, and Hexadimethrine Bromide - PMC.
1 Οκτ 2018 · Coagulation factor II, or prothrombin, is a multi-domain glycoprotein that is essential for life and a key target of anticoagulant therapy. In plasma, prothrombin circulates in two forms at equilibrium, “closed” (~80%) and “open” (~20%), brokered by the flexibility of the linker regions.
In order to determine whether the levels of prothrombin or other plasma clotting factors might play a role in the thrombotic tendency in diabetes, we assayed clotting times, and prothrombin, antithrombin, fibrinogen and plasminogen activator inhibitor‐1 (PAI‐1) levels in subjects with or without type 2 DM.
13 Φεβ 2018 · Together with functional studies, our findings define the role of closed and open conformations in the conversion of prothrombin to thrombin and establish a molecular framework for...
The exact role of proaccelerin in human blood coagulation has not been settled with certainty and it is proposed that prothrombin cannot be converted to thrombin in the absence of proACcelerin and that proac acceleration manifests its action after activation by some clotting factor other than thromboplastin.
