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  1. In dogs, there are no signs during the early stages of the disease, although a heart murmur can be heard. As the disease becomes severe and overwhelming, left-sided heart failure can develop, and affected dogs may be unwilling to move or exercise, have difficulty breathing, and develop a cough.

  2. Heart Sounds and Murmurs. Heart sounds are produced by the rapid acceleration and deceleration of blood and the resulting vibrations in the heart due to the circulation of blood. They can be heard using a stethoscope. In dogs, 2 heart sounds can normally be distinguished.

  3. Infected dogs may have nosebleeds, bruises, blood in the urine, bleeding into the bowel, or bleeding of the retina (the membrane at the back of the eye). In severely affected dogs, disseminated intravascular coagulation may occur ( see Acquired Clotting Protein Disorders).

  4. Blood disorders are quite diverse. They can occur as normal responses to abnormal situations; for example, a significant increase in the number of white blood cells in response to an infection or disease.

  5. This causes weak structural support of blood vessels and can result in hematoma formation and easy bruising. The disorder has been reported in dogs, cats, mink, horses, cattle, sheep, and people but is rare in domestic animals. The most striking clinical abnormality is loose, hyperextensible skin that tears easily.

  6. 29 Σεπ 2024 · Type 1 von Willebrand Disease in dogs. Type 1 von Willebrand Disease is the most common type, and also the mildest. It occurs when dogs have a mild deficiency in all the proteins making up their von Willebrand factor, but the proteins have a normal structure. These dogs may have no symptoms or have slow clotting that doesn’t cause major issues.

  7. What are some of the signs of vWD? Many dogs with vWD never show outward evidence of having the disease. Others may spontaneously hemorrhage from the nose, vagina, urinary bladder, or oral mucous membranes.