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  1. Look on the wiki and clear challenges that give you items. I would suggest challenges 2 (unlocks Jera), 9 (Chaos Card), 10 (Credit Card), 12 (Card Against Humanity), 15 (Swallowed Penny), 17 (Death's Touch), and 18 (Technology .5). These challenges give some of the most beginner-friendly items.

  2. Challenges are unique runs in the game. Isaac typically starts each challenge with one or more specific items which makes normal play more difficult. With few exceptions, Treasure Rooms are not available during challenges. Each challenge unlocks new content for the game, such as runes, when...

  3. I only have Rebirth + Afterbirth (so 30 challenges in total), and I'd like to know which ones I should complete as soon as possible for their reward. So which "challenge items" are good and should be unlocked quickly?

  4. The official subreddit for Edmund McMillen's Zelda-inspired roguelite, The Binding of Isaac! The title says it all basically I just want some tips on the best low difficulty to high reward challenges for repentance.Thx!

  5. I made this post a while ago asking people what are the best challenges to complete first for the unlocks, and I got a lot of valuable responses! Check it out, I'm sure it will help you just as much as is has helped me!

  6. XXXXXXXXL is also the only Afterbirth challenge that has good rewards and isn't too difficult. Gold Bombs are great, but require Blue Bomber, which is tough. Meanwhile, Pay to Play and Have a Heart aren't that tough, but unlock new pills that you don't want. Computer Savvy is easy, but unlocks Robo-Baby 2.0, which isn't that good.

  7. The Binding of Isaac: Rebirth is a randomly generated action RPG shooter with heavy roguelike elements. Players will accompany Isaac on a quest to escape his mother, facing off against droves of mysterious creatures, discovering secrets, and fighting fearsome bosses.