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Look up Frederick Bordwell's stuff. TONS of data on pKa's and even some stuff in non-aqueous solutions. https://scholar.google.com/scholar?q=pka+author%3AFG+bordwell&btnG=&hl=en&as_sdt=0%2C5
Pka's apply to synthesis and mechanisms. Here's my take on how... Say you want to make a compound and you need a grignard or organolithium to make some carbon-carbon bond. Both of those are incredibly strong bases that will react with acidic protons on your molecule before they'd act in the way you intend them to.
Does anyone know of any online free or cheap software that can roughly calculate the PKA of an organic compound? I'm working with a lot of synthetic cannabinoids that have a protonatable nitrogen and need roughly their PKA values.
27 Οκτ 2017 · Below are tables that include determined pKa values for various acids as determined in water, DMSO and in the gas Phase. These tables are compiled in PDF files below. For a more comprehensive discussion on this topic, please see Acidity and Basicity by professor William Reusch, Michigan State University.
18 Ιουν 2010 · To calculate the Isoelectric point of an amino acid or peptide (or protein, if you are daring), you take the pKa of the carboxylic acid (between 2 and 4 usually) and the amine (9-11), add them, and divide by 2 for the case of an amino acid with no side chain that has a pKa value.
16 Δεκ 2021 · For example, acetic acid CH 3 COOH has a Ka of 1.8×10-5. Lots of other organic acids are even weaker than acetic acid, and it is this weak acidity that makes it difficult to realize that some organic compounds are actually acids.
The pKa measures the "strength" of a Bronsted acid. A proton, H + , is a strong Lewis acid; it attracts electron pairs very effectively, so much so that it is almost always attached to an electron donor.
