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In summary, several randomized clinical trials suggest that the supplementation with CoQ10 may be beneficial in migraineurs in respect to reduction headache severity, frequency, and duration of headache attacks, with no side effects.
8 Μαΐ 2017 · What is new and conclusion. Riboflavin is well tolerated, inexpensive and has demonstrated efficacy in the reduction of adult patient's migraine headache frequency. Additional data are needed, however, to resolve questions involving pharmacokinetic issues and pharmacogenomic implications of therapy.
Research in migraineurs has demonstrated elevated levels of various oxidative stress markers and pro-inflammatory cytokines, and a migraine preventive effect of riboflavin. Animal models have also shown that riboflavin reduces these markers.
Objective: We conducted a short review of relevant literature which contends that migraine is associated with a wide-spread metabolic abnormality of mitochondrial oxidative metabolism, leading to the use of riboflavin and coenzyme Q10 as prophylactic therapy for migraine.
In parallel with the development of novel therapeutics for migraine, there is a growing body of literature on the use of neuromodulatory non-pharmacologic approaches, such as nutraceuticals (e.g., riboflavin, coenzyme Q10, magnesium, vitamin D, and melatonin) or behavioral therapies (15).
No side effects for CoQ10 were observed. This study suggests that CoQ10 might reduce the frequency of headaches, and may also make them shorter in duration, and less severe, with a favorable safety profile. Keywords: Coenzyme q10; Headache; Migraine; Prophylaxis. Publication types. Clinical Trial. MeSH terms. Adult.
Nausea event caused by migraine improved with CoQ10 but was limited in the number of the trials. Report on adverse events was limited to the minor side effects, which include episodes of diarrhoea and chromaturia and showed no difference with CoQ10.
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