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Each individual muscle is surrounded by epimysial connective tissue and within the muscle there are two distinct extracellular matrix (ECM) structures, the perimysium and endomysium. Together, these three ECM structures make up the intramuscular connective tissue (IMCT).
The cells play an important role in normal development of fibers and in regeneration of damaged fibers by serving as stem cells that can be activated to undergo mitosis in adult life and subsequently differentiate to myoblasts, myotubes, and, eventually, mature myofibers.
Inside each fascicle, each muscle fiber is encased in a thin connective tissue layer of collagen and reticular fibers called the endomysium. The endomysium surrounds the extracellular matrix of the cells and plays a role in transferring force produced by the muscle fibers to the tendons.
Endomysium is the deepest and smallest component of muscle connective tissue. This thin layer helps provide an appropriate chemical environment for the exchange of calcium, sodium, and potassium, which is essential for the excitation and subsequent contraction of a muscle fiber.
The endomysium is the key element that separates single muscle fibres from one another. It allows their autonomous gliding during muscle contraction. The endomysium is also a highly deformable tissue that adapts itself to the changes of volume that occur during the muscle fibre contraction.
1 Ιαν 2013 · The endomysium, perimysium, epimysium and deep fasciae have not just a role of containment, limiting the expansion of the muscle with the disposition in concentric layers of the collagen tissue, but are fundamental elements for the transmission of muscular force, each one with a specific role.
The endomysium encases individual muscle fibers, providing structural support, transmitting contractile forces, and assisting in nutrient exchange between blood vessels and muscle cells. It contributes to muscle elasticity and is integral in muscle repair and regeneration.
