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17 Φεβ 2020 · Depressive disorders are common, costly, have a strong effect on quality of life, and are associated with considerable morbidity and mortality. Effective treatments are available: antidepressant medication and talking therapies are included in most guidelines as first-line treatments.
Treatment for depression exists, such as pharmacotherapy, cognitive behavioural therapy, and other modalities. A meta-analysis of randomized, placebo-controlled trials of patients shows that 56–60% of people respond well to active treatment with antidepressants (selective serotonin reuptake inhibitors, tricyclic antidepressants) [9].
1 Μαρ 2023 · We clearly need better treatments for major depression as our current treatments are ineffective or intolerable for numerous individuals. This issue of the Journal brings together papers that are focused on how we can better understand mood disorders and improve the efficacy of our treatments.
29 Ιουν 2022 · This guideline covers identifying, treating and managing depression in people aged 18 and over. It recommends treatments for first episodes of depression, further-line treatments, and provides advice on preventing relapse and managing chronic depression, psychotic depression and depression with a coexisting diagnosis of personality disorder.
14 Ιαν 2023 · Although psychosocial interventions might also be recommended, more effective treatments than those currently available are needed for people with moderate or severe depression. In the past 10 years, treatment trials have developed and tested many new targeted interventions.
9 Φεβ 2024 · Systemic treatment with LPS induces depressive-like behaviors and increases the production of inducible nitric oxide synthase (iNOS), IL-1β, TNF-α, and GFAP in the hippocampus and cortex.
This is the first review of systematic reviews assessing the benefits and harms of more than 140 pharmacological and non-pharmacological treatments for major depressive disorder. We used rigorous systematic review and novel graphical methods to summarise treatment effects and present the strength of the underlying evidence.
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