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1. How to evaluate and manage a sickle cell disease patient with pain crisis, and when to admit? 2. How to evaluate and manage a sickle cell disease patient with a fever, and when to admit? 3. How to evaluate and manage a sickle cell disease patient with suspected Acute Chest Syndrome? 4.
10 Σεπ 2020 · Sickle cell disease (SCD) refers to a group of inherited red blood cell (RBC) disorders resulting from a mutation in hemoglobin, which impedes regular blood flow and leads to painful vaso-occlusive episodes and other severe complications (CDC, 2017b).
Sickle cell disease (SCD) is a monogenetic disorder due to a single base-pair point mutation in the β-globin gene resulting in the substitution of the amino acid valine for glutamic acid in the β-globin chain. Phenotypic variation in the clinical presentation and disease outcome is a characteristic feature of the disorder.
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