Αποτελέσματα Αναζήτησης
Study with Quizlet and memorize flashcards containing terms like What is the primary cause of sickle cell anemia?
Study with Quizlet and memorize flashcards containing terms like What is sickle cell disease?, What is the pathophysiology of sickle cell disease?, What is the epidemiology of sickle cell disease? and more.
Study with Quizlet and memorize flashcards containing terms like sickle cell disease (SCD), sickle cell anemia, sickling and more.
Sickle cell disease (SCD) is a monogenetic disorder due to a single base-pair point mutation in the β-globin gene resulting in the substitution of the amino acid valine for glutamic acid in the β-globin chain. Phenotypic variation in the clinical presentation and disease outcome is a characteristic feature of the disorder.
24 Ιαν 2019 · Based on current evidence, the pathobiology of SCD is considered to be a vicious cycle of four major processes, all the subject of active study and novel therapeutic targeting: ( a) hemoglobin S polymerization, ( b) impaired biorheology and increased adhesion-mediated vaso-occlusion, ( c) hemolysis-mediated endothelial dysfunction, and ( d) conc...
11 Οκτ 2024 · Study with Quizlet and memorize flashcards containing terms like sickle cell disease, hemoglobin, mutation and more.
4 Σεπ 2023 · Pathophysiology. Sickle cell anemia is characterized by two major components: Hemolysis and vaso-occlusive crises (VOC). The defect in the beta-globin gene makes the sickle hemoglobin (HbS) molecule susceptible to converting into rigid, elongated polymers in a deoxygenated state.
