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Statins have long been used for the protection against coronary artery disease (CAD). Their beneficial effect apart from cholesterol reduction lies in their pleiotropic properties.
- Statins stimulate atherosclerosis and heart failure ... - PubMed
Statins inhibit the synthesis of vitamin K2, the cofactor...
- Statins stimulate atherosclerosis and heart failure ... - PubMed
1 Σεπ 2000 · Statins decrease the adhesion of monocyte to endothelial cells. Accordingly, statins exert their cardiovascular benefits through a direct antiatherogenic properties in the arterial wall, beyond their effects on plasma lipids.
10 Νοε 2021 · Statin therapy appears to accelerate the process of transforming a potentially highly metabolically active plaque to a more inert state. Specifically, statin therapy is associated with a decrease in low-attenuation and fibro-fatty plaque volumes and an increase in high-density and 1K volumes.
6 Μαΐ 2020 · 200 Citations. 5 Altmetric. Explore all metrics. Abstract. Atherosclerosis is one type of cardiovascular disease (CVD) in which activation of the NLRP3 inflammasome and toll-like receptor (TLR) pathways is implicated. One of the most effective treatments for atherosclerosis is the use of statin medications.
Statins inhibit the synthesis of vitamin K2, the cofactor for matrix Gla-protein activation, which in turn protects arteries from calcification. Statins inhibit the biosynthesis of selenium containing proteins, one of which is glutathione peroxidase serving to suppress peroxidative stress.
1 Οκτ 2022 · High levels of LDL can lead to fatty deposits (plaque) in artery walls throughout the body. By limiting plaque buildup in the arteries that feed the heart (coronary arteries) and those that supply blood to the brain, statins help prevent heart disease and stroke. But statins do even more.
18 Ιαν 2000 · Statins are the most commonly prescribed agents for the treatment of hypercholesterolemia because of their efficacy in reducing LDL and their excellent tolerability and safety. This review examines the pharmacology, clinical trials, and proposed mechanisms of clinical benefits of statins.
