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21 Οκτ 2019 · Metals are thought to play structural and chemical roles as cofactors of more than one-third of the proteome of most organisms, (1−3) and their mobilization offers one of the most widespread forms of signaling for regulation of cellular function.
Summary. Transition metals (Fe, Cu, Mo, Cr, Co, Mn, V) play key roles in such biological processes as cell division (Fe, Co), respiration (Fe, Cu), nitrogen fixation (Fe, Mo, V), and photosynthesis (Mn, Fe). Zn participates in many hydrolytic reactions and in the control of gene activity by proteins with "zinc fingers."
As bioinorganic chemists focus more on the roles of metal ions in cells and whole organisms, future developments in the field are likely to again result from methodological advances, including...
23 Αυγ 2021 · Among the transition metals used in living organisms, iron is the most abundant in the environment. Whether this fact alone explains the biological predominance of iron or whether specific features of iron chemistry contribute is not clear.
1 Ιαν 2019 · In this review, to focus on host–guest chemistry and applications in biology and biochemistry, we provide an overview of recent examples of BioMOFs comprising multifunctional biomolecular ligands and transition metal ions.
Both pathogens and hosts have complex regulatory systems for metal homeostasis. Understanding these provides strategies for fighting pathogens, either by excluding essential metals from the microbes, by delivery of excess metals to cause toxicity, or by complexing metals in microorganisms.
2 Δεκ 2011 · Recent advances in mass spectrometry, X-ray scattering/absorption, and proteomics have exposed a much broader usage of metals in biology than expected.
