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In E. coli, type I topoisomerase can only relieve negatively supercoiled DNA (negative supercoiling is the end result of newly replicated DNA genome). In eukaryotes, type I topoisomerase can also relieve positively supercoiled DNA. The net result of E. coli topoI can be diagrammed as follows: Figure 1.6.4: E. Coli Topoisomerase I
18 Απρ 2018 · In organisms living in the range of mesophilic temperatures, DNA is in general negatively supercoiled (−SC); thermophilic microorganisms, living in environmental niches above 70 °C, possess a...
24 Δεκ 2022 · Key Points. As a general rule, the DNA of most organisms is negatively supercoiled. The simple figure eight is the simplest supercoil, and is the shape a circular DNA assumes to accommodate one too many or one too few helical twists. DNA supercoiling is important for DNA packaging within all cells.
21 Σεπ 2001 · Supercoiling provides a significant amount of free energy to DNA molecules and, inside cells, this can be used to drive structural transitions and other metabolic processes that would normally be...
Supercoiling is a fundamental property of DNA and chromatin. It is modulated by polymerase and topoisomerase activities and, through regulated constraint, by DNA/chromatin binding proteins.
DNA supercoiling defines the phenomenon whereby the actual linking number Lk differs from Lk 0. The handedness of supercoils is positive when they are in the same direction as the double helix (right‐handed), that is, DNA is over‐wound (Lk >Lk 0), and negative when DNA is under‐wound (Lk <Lk 0).
DNA supercoiling is a naturally-occurring biological process when a DNA replisome or an RNA polymerase (RNAP) unwinds and translocates on the DNA to synthesize DNA or RNA. From: Genomics, Proteomics & Bioinformatics, 2016
