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Study with Quizlet and memorize flashcards containing terms like A. Negative supercoiled DNA is under-rotated and allows for easier strand separation during replication and transcription., Relaxed DNA, B. Negatively supercoiled 300bp /10 bp/rotation =30 rotations 20 is less than 30 so the molecular is negative. and more.
Supercoiling is controlled by topoisomerase enzymes. Most cellular DNA is negatively supercoiled, which eases the separation of nucleotide strands during replication and transcription and allows the DNA to be packed into small spaces. A DNA molecule 300 bp long has 20 complete rotations.
Study with Quizlet and memorize flashcards containing terms like supercoiled DNA represents the _____ structure, right-handed, left-handed and more.
18 Ιουλ 2019 · Policing of the local and global supercoiling of DNA by topoisomerases helps to sustain the major DNA-based transactions by eliminating barriers to the movement of transcription complexes and replisomes.
17 Φεβ 2013 · DNA supercoiling is an inherent consequence of twisting DNA and is critical for regulating gene expression and DNA replication. However, DNA supercoiling at a genomic scale in human...
12 Οκτ 2015 · As negative supercoiling increases, bases are increasingly exposed. Beyond a sharp supercoiling threshold, we also detect exposed bases in positively supercoiled DNA.
Supercoiling is a fundamental property of DNA and chromatin. It is modulated by polymerase and topoisomerase activities and, through regulated constraint, by DNA/chromatin binding proteins. As a non-covalent and elusive topological modification, ...