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Melanoma in situ is an early form of primary melanoma in which the malignant cells are confined to the tissue of origin, the epidermis. It is also known as in-situ melanoma and level 1 melanoma.
Superficial spreading melanoma is a form of melanoma in which the malignant cells tend to stay within the epidermis (‘in situ’ phase) for a prolonged period (months to decades). At first, superficial spreading melanoma grows horizontally in the skin – this is known as the radial growth phase, presenting as a slowly-enlarging flat area of ...
Melanoma in situ is the earliest stage of melanoma (stage 0) and is localized to the outermost layer of skin (epidermis). It is regarded as a potential precursor lesion to invasive melanoma (stages I to IV), in which melanoma invades the deeper layers of the skin and, in doing so, acquires the potential ability to spread to distant sites, which ...
31 Ιαν 2019 · The main risk factors for developing the more common type of melanoma (eg, superficial spreading melanoma) include: Increasing age; Previous invasive melanoma or melanoma in situ; Previous basal cell or squamous cell carcinoma; Many melanocytic naevi ; Multiple (>5) atypical naevi (large or histologically dysplastic moles)
Melanoma in situ (MIS) poses special challenges with regard to histopathology, treatment, and clinical management. The negligible mortality and normal life expectancy associated with patients with MIS should guide treatment for this tumor.
Our understanding of melanoma in situ has been shaped by epidemiologic and clinical studies. Central to a review of melanoma in situ is a focus on its epidemiology, pathology, biologic behavior, treatment, and clinical outcome, which may differ significantly from that of malignant melanoma.
Results. We describe the various surgical and tissue processing techniques and discuss advantages and disadvantages of each. Limitations. This paper was styled as a narrative review defining and clarifying terminology and technique and does not investigate these topics more broadly. Conclusion.
