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SV40 is an abbreviation for simian vacuolating virus 40 or simian virus 40, a polyomavirus that is found in both monkeys and humans. Like other polyomaviruses, SV40 is a DNA virus that sometimes causes tumors in animals, but most often persists as a latent infection.
9 Ιουλ 2007 · Simian virus 40 (SV40) is a monkey virus that was administered to human populations by contaminated vaccines which were produced in SV40 naturally infected monkey cells.
Natural exposure to SV40 in humans is considered a rare event, and antibodies to SV40 can be demonstrated only in people who have been in contact with monkeys (Shah, 1966; Engels et al., 2004a) or who had received, in the past, SV40-contaminated poliovirus vaccine.
1 Μαρ 2022 · The extensive poliovirus vaccination programs of the late 1950s and early 1960s lead to the accidental infection of millions of individuals with an unknown virus (SV40) possessing cancer-causing potential. This mistake sparked a massive research enterprise to...
31 Ιουλ 2004 · However, two Merck researchers, Ben Sweet and Maurice Hilleman, soon identified the rhesus virus later named SV40—the carcinogenic agent that had eluded Eddy. In 1963, US authorities decided to switch to African green monkeys, which are not natural hosts of SV40, to produce polio vaccine.
The simian virus 40 (SV40) is a close relative of BKPyV and JCPyV and replicates particularly well in kidney cells of Old World monkeys, including the rhesus monkey and African green monkey (Butel & Lednicky, 1999). The genome of all polyomaviruses is organized as a circular double-stranded DNA of ~5 kb with a non-coding control region (NCCR ...
The polyomavirus simian virus 40 (SV40) is a known oncogenic DNA virus which induces primary brain and bone cancers, malignant mesothelioma, and lymphomas in laboratory animals. Persuasive evidence now indicates that SV40 is causing infections in humans today and represents an emerging pathogen.
