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SV40 is an abbreviation for simian vacuolating virus 40 or simian virus 40, a polyomavirus that is found in both monkeys and humans. Like other polyomaviruses, SV40 is a DNA virus that sometimes causes tumors in animals, but most often persists as a latent infection.
1 Μαρ 2022 · The extensive poliovirus vaccination programs of the late 1950s and early 1960s lead to the accidental infection of millions of individuals with an unknown virus (SV40) possessing cancer-causing potential. This mistake sparked a massive research enterprise to...
SV40 is a small DNA tumor virus with a genome that can be readily manipulated by scientists because of its simplicity. The capsid of SV40 is spherical and has such limited space that the genome is only large enough to encode a few functions.
9 Ιουλ 2007 · Simian virus 40 (SV40) is a monkey virus that was administered to human populations by contaminated vaccines which were produced in SV40 naturally infected monkey cells.
While the human polyomaviruses BKV and JCV are ubiquitous in humans, SV40 is a simian virus which was introduced in the human population, between 1955 and 1963, by contaminated poliovaccines produced in SV40- infected monkey cells.
The COS-7 cell line was derived by Yakov Gluzman in the early 1980s from the previously established CV-1 African green monkey kidney line by transformation of the normal cells with an origin defective mutant of simian virus 40 (SV40) that codes for the wild-type virus T-antigen.
31 Ιουλ 2004 · However, two Merck researchers, Ben Sweet and Maurice Hilleman, soon identified the rhesus virus later named SV40—the carcinogenic agent that had eluded Eddy. In 1963, US authorities decided to switch to African green monkeys, which are not natural hosts of SV40, to produce polio vaccine.
