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SV40 is an abbreviation for simian vacuolating virus 40 or simian virus 40, a polyomavirus that is found in both monkeys and humans. Like other polyomaviruses, SV40 is a DNA virus that sometimes causes tumors in animals, but most often persists as a latent infection.
9 Ιουλ 2007 · Simian virus 40 (SV40) is a monkey virus that was administered to human populations by contaminated vaccines which were produced in SV40 naturally infected monkey cells.
This variant of SV40-Baylor has an archetypal viral regulatory region and can be used in viral growth studies for comparison with SV40-B2, the commonly used laboratory variant of SV40-Baylor. Contains a full-length genome of SV40-B1 cloned into pUC-19 at the EcoRI site.
31 Ιουλ 2004 · However, two Merck researchers, Ben Sweet and Maurice Hilleman, soon identified the rhesus virus later named SV40—the carcinogenic agent that had eluded Eddy. In 1963, US authorities decided to switch to African green monkeys, which are not natural hosts of SV40, to produce polio vaccine.
1 Μαρ 2022 · The extensive poliovirus vaccination programs of the late 1950s and early 1960s lead to the accidental infection of millions of individuals with an unknown virus (SV40) possessing cancer-causing potential. This mistake sparked a massive research enterprise to...
20 Ιαν 1999 · SV40 is a potent DNA tumor virus that induces tumors in rodents and transforms many types of cells in culture, including those of human origin. This virus has been a favored laboratory model for mechanistic studies of molecular processes in eukaryotic cells and of cellular transformation.
The polyomavirus simian virus 40 (SV40) is a known oncogenic DNA virus which induces primary brain and bone cancers, malignant mesothelioma, and lymphomas in laboratory animals. Persuasive evidence now indicates that SV40 is causing infections in humans today and represents an emerging pathogen.
