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As their name suggests, T helper (Th) cells provide helper functions to other cells of the immune system—especially the antigen-presenting cells (APCs) such as macrophages, dendritic cells, and B cells—and are important for their activation and maturation.
What does it mean if your Total T-Helper-1 Cell result is too high? Elevated levels of Total T-Helper-1 (Th1) cells can indicate a heightened state of immune system activation specifically geared towards fighting intracellular pathogens, such as viruses and certain types of bacteria.
The T helper cells (Th1 cells) are a subset of CD4+ T cells which are characterized by releasing cytokines like interferon gamma (IFN-γ), IL-2, and tumor necrosis factor alpha (TNF-α) to activate other immune cells and contribute to cellular immune responses.
T helper (Th)1 cells, which produce interferon (IFN)-γ, are crucial for the eradication of intracellular parasites, whereas Th2 cells, which produce interleukin (IL)-4, IL-5 and IL-13, are important for the regulation of the immune response to helminthes.
T helper 1 (Th1) cells primarily produce IFN-γ and are critical for the immune responses to various viral infections, as well as infections with intracellular bacteria. This subclass of effector cells is typically associated with antiviral cell-mediated immunity.
15 Οκτ 2024 · Depending on which APC-secreted cytokines interact with an activated helper T cell, the cell may differentiate into a T helper 1 (T H 1) cell, a T helper 2 (T H 2) cell, or a memory helper T cell. The two types of helper T cells are relatively short-lived effector cells, meaning that they perform various functions of the immediate immune response.
15 Μαΐ 2024 · In this article, development and functions of different subsets of helper T cells (T H 1, T H 2, T H 17 and T FH) are illustrated, and their roles in different hypersensitivity reactions are discussed.