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26 Ιουν 2015 · Notch 1 Is Involved in CD4+ T Cell Differentiation Into Th1 Subtype During Helicobacter pylori Infection. Helicobacter pylori infection induces CD4+ T differentiation cells into IFN-γ-producing Th1 cells. However, the details of mechanism underlying this process remain unclear.
THP-1 is a monocyte isolated from peripheral blood from an acute monocytic leukemia patient. This cell line can be used in immune system disorder research, immunology research, and toxicology research. Note: These are suspension cells and floating cells are viable. Discounts may be available for our fellow nonprofit organizations.
T Cell Differentiation Kits: Products. CD4+ T cells can differentiate into T helper (Th)1, Th2, Th17, and Regulatory T (Treg) cells by exposure to various cytokines and cellular interactions that induce the expression of specific sets of transcription factors. Differentiation into Th1 cells is promoted through IL-12 and IFN-gamma.
ImmunoCult™ Human Th1 Differentiation Supplement contains a combination of human cytokines and a blocking antibody formulated to promote the robust activation, expansion, and differentiation of peripheral blood-derived, naïve, CD4+ human T cells into Th1 cells.
The BD™ CBA Human Th1/Th2 Cytokine Kit (Catalog No. 550749) can be used to quantitatively measure Interleukin-2 (IL-2), Interleukin-4 (IL-4), Interleukin-5 (IL-5), Interleukin-10 (IL-10), Tumor Necrosis Factor (TNF), and Interferon-γ (IFN-γ) protein levels in a single sample.
As their name suggests, T helper (Th) cells provide helper functions to other cells of the immune system—especially the antigen-presenting cells (APCs) such as macrophages, dendritic cells, and B cells—and are important for their activation and maturation.
These cells express an NF-κB-inducible SEAP reporter gene, which enables rapid colorimetric detection, measurable in the cell culture supernatant when using QUANTI-Blue™. To follow inflammasome assembly or cell death, we provide THP-1-derived cell lines harboring GFP or Lucia fusion proteins.
