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The therapeutic index (TI; also referred to as therapeutic ratio) is a quantitative measurement of the relative safety of a drug with regard to risk of overdose.
30 Ιουν 2015 · The therapeutic index is the ratio of the TD 50 to the ED 50 , a parameter which reflects the selectivity of a drug to elicit a desired effect rather than toxicity.
22 Μαρ 2024 · The therapeutic index (TI), also known as the therapeutic window, is a critical pharmacological parameter used to assess the safety and efficacy of a drug. It quantifies the relative safety of a medication by comparing the dose required to produce therapeutic effects with the dose that causes toxicity.
Figure. Dose–response curves for the beneficial and adverse effects of a drug. Prescribers will aim to prescribe doses that maximize benefits and minimize harms, which is easier for drugs where the ratio between the dose causing harm and that causing benefit (the ’therapeutic index’) is high.
The therapeutic index (ratio of the minimum toxic concentration to the median effective concentration) helps determine the efficacy and safety of a drug. Increasing the dose of a drug with a small therapeutic index increases the probability of toxicity and/or ineffectiveness of the drug.
31 Αυγ 2012 · The therapeutic index (TI) — which is typically considered as the ratio of the highest exposure to the drug that results in no toxicity to the exposure that produces the desired efficacy — is an...
The therapeutic index represents the relationship between concentrations causing adverse effects and concentrations causing desired effects. It is usually EC50 (adverse effect)/EC50 (desired effect) Drugs with a high or large therapeutic index are desirable in practice.
