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Thymine is integral DNA and RNA building blocks and thus playes an essential role in biological processes. Some scaffolds containing the thymine heterocycle exhibit excellent anticancer activity [103–105].
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31 Ιαν 2024 · Thiamine, also known as thiamin and vitamin B1, is one of the 8 B-complex vitamins and is classified as a water-soluble B vitamin. Thiamine occurs naturally in specific diets, is added to food products, and is available in dietary supplements.
2 Οκτ 2024 · We identify seven previously unknown drug interactions of SLC19A3 and present structures of the transporter in complex with the inhibitors fedratinib, amprolium and hydroxychloroquine.
Therefore, thiamine is considered as drug or diet supplement which can support the treatment of many pathologies including neurodegenerative and vascular system diseases. On the other hand, thiamine antivitamins, which can interact with thiamine-dependent enzymes impeding their native functions, thiamine transport into the cells or a thiamine ...
Thymine is 5-methyl uracil with similar unsaturated ring. Thymine name sounds like thymus gland, the source of isolation of this molecule was found in 1893 by Albert Neumann and Albrecht Kossel. Most important products of thymine are dTMP, dTDP and dTTP (sugar present is deoxyribose here).
Thymine DNA Glycosylase (TDG) is a DNA repair protein that plays an important role in gene regulation. Recent studies have shown that TDG interacts with various transcription factors to activate target genes.
