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Thymine is integral DNA and RNA building blocks and thus playes an essential role in biological processes. Some scaffolds containing the thymine heterocycle exhibit excellent anticancer activity [103–105].
Thymine. Thymine is 5-methyl uracil with similar unsaturated ring. Thymine name sounds like thymus gland, the source of isolation of this molecule was found in 1893 by Albert Neumann and Albrecht Kossel. Most important products of thymine are dTMP, dTDP and dTTP (sugar present is deoxyribose here).
18 Μαρ 2021 · Thymine, which is often abbreviated as T or Thy, can also be referred to as 5-methyluracil. Thymine is one of the pyrimidine bases found in the nucleic acid of deoxyribonucleic acid (DNA),...
Tritiated thymidine, targeted using autoradiography was technically demanding and superseded by 5-bromo-2-deoxyuridine (BrdU) and related halogenated analogues, detected using antibodies. Their detection required the denaturation of DNA, often constraining the outcome of investigations.
Thymine DNA Glycosylase (TDG) is a DNA repair protein that plays an important role in gene regulation. Recent studies have shown that TDG interacts with various transcription factors to activate target genes.
Thymine is integral DNA and RNA building blocks and thus playes an essential role in biological processes. Some scaffolds containing the thymine heterocycle exhibit excellent anticancer activity [ 103–105 ].
16 Απρ 2009 · Thymine, one of the four ubiquitous DNA bases, is synthesized by the enzyme thymidylate synthase, which catalyses the methylation of the uracil moiety of 2′-deoxyuridine-5′-monophosphate.
